Literature

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Epidemiology

  • Chen et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020.

  • Ferguson et al. Impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand. Imperial College London. March 16, 2020.

  • Ki et al. Epidemiologic characteristics of early cases with 2019 novel coronavirus (2019-nCoV) disease in Korea. Epidemiol Health. 2020.

  • Lin, Xihong. Analysis of 25,000+ COVID-19 cases in Wuhan: Epidemiological characteristics and effects of non-pharmaceutical interventions. Webinar, slides. 2020.

  • Field Brief: Diamond Princess COVID-19 Cases. National Institute of Infectious Diseases.

  • Li et al. Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2). Science. March 16, 2020. - Based on Wuhan models, estimated 86% of true positive COVID cases are undocumented.

Clinical Course

  • Arentz et al. Characteristics and Outcomes of 21 Critically Ill Patients with COVID-19 in Washington State. JAMA. March 19, 2020. - For severe ICU patients, 67% mortality and 10% discharge.

  • Weiss and Murdoch. Clinical course and mortality risk of severe COVID-19. The Lancet. March 17, 2020.

  • Guan et al. Clinical Characteristics of Coronavirus Disease 2019 in China. NEJM. 2020

  • Hu et al. Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China. Science China Life Sciences. 2020.

  • Wang et al. Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020.

  • Wu et al. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases From the Chinese CDC. JAMA. 2020.

  • Yanh et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine. 2020.

  • Zhou et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020.

  • Holshue et al. First Case of 2019 Novel Coronavirus in the United States. NEJM. 2020.

  • Pan et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study. Amer Jour Gastroenterology. 2020. - Study suggesting some COVID-19 patients present with GI Sx as primary complaint - and 7% as only complaint.

Testing

  • Peng et al. Findings of lung ultrasonography of novel coronavirus pneumonia during the 2019-2020 epidemic. Intensive Care Med. 2020.

  • Xie et al. Chest CT for Typical 2019-nCoV Pneumonia: Relationship to Negative RT-PCR Testing. Radiology. 2020.

  • Zhao et al. Relation Between Chest CT Finding and Clinical Conditions of Coronavirus Disease (COVID-19) Pneumonia: A Multicenter Study. American Journal of Roentgenology. 2020.

  • FDA greenlights first 45-minute, point-of-care coronavirus diagnostic test.

PPE / Masks

  • Santarpia et al. Transmission Potential of SARS-CoV-2 in Viral Shedding Observed at the University of Nebraska Medical Center. medRxiv. March 26, 2020. - Study showing that the virus can be found in up to 85% of objects in a patient’s room, even up to day 18 of hospitalization. 66% of samples of the HALLWAY outside the rooms were positive too.

  • Doremalen et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. NEJM 2020.

  • Kampf et al. Persistence of cornaviruses on inanimate surfaces and their inactivation with biocidal agents. Journal of Hospital Infection. 2020.

  • MacIntyre et al. A cluster randomised trial of cloth masks compared with medical masks in healthcare workers. BMJ Open. 2015.

  • Boston Children’s Hospital: Reusable Elastomeric Respirator.

  • Stanford Recommendations for Face Mask Shortages. March 22, 2020. - Evidence that N95s can be re-used after 70C in oven 30 min.

  • SAGES Recommendations for Re-using N95 Masks

  • Nebraska Medicine Protocol for Decontaminating N95 Masks with UV

Treatments

  • Wang et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCov) in vitro. Cell Research. 2020.

  • Russell et al. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. The Lancet. 2020.

  • Lim et al. The Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR. JKMS. 2020.

  • Shen et al. Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. JAMA. March 27, 2020. - First data showing plasma transfusion improved fevers and viral loads within 12 days of transfusion.